Marjolein Van den Boogert

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BACKGROUND Transient receptor potential (TRP) channels are a superfamily of broadly expressed ion channels with diverse physiological roles. TRPC1, TRPC3, and TRPC6 are believed to contribute to cardiac hypertrophy in mouse models. Human mutations in TRPM4 have been linked to progressive familial heart block. TRPM7 is a divalent-permeant channel and kinase(More)
Sick sinus syndrome and atrioventricular block are common clinical problems, often necessitating permanent pacemaker placement, yet the pathophysiology of these conditions remains poorly understood. Here we show that Transient Receptor Potential Melastatin 7 (TRPM7), a divalent-permeant channel-kinase of unknown function, is highly expressed in embryonic(More)
  • B.-W, Inserm U, +14 authors Arrhythmia Electrophysiology
  • 2013
T ransient receptor potential (TRP) channels are a loosely related family of ion channels that share the properties of cation permeability and minimal voltage sensitivity. With respect to cardiac physiology and disease, most interest to date has focused on the TRPC channels (1, 3, 4, and 6) that, by permeating calcium, can activate calcineurin-nuclear(More)
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