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  • Viktor Szatmári, Erik Teske, Peter G J Nikkels, Matthias Griese, Pim A de Jong, Guy Grinwis +5 others
  • 2015
BACKGROUND Pulmonary alveolar proteinosis is an extremely rare lung disease in animals and humans. It is characterized by the deposition of a large amount of phospholipoproteinaceous material in the alveoli. There are several possible etiologies, both congenital and acquired. Alveolar macrophages play an important role in the clearance of surfactant. This(More)
  • Lesley Ann Saketkoo, Shikha Mittoo, Dörte Huscher, Dinesh Khanna, Paul F Dellaripa, Oliver Distler +257 others
  • 2014
RATIONALE Clinical trial design in interstitial lung diseases (ILDs) has been hampered by lack of consensus on appropriate outcome measures for reliably assessing treatment response. In the setting of connective tissue diseases (CTDs), some measures of ILD disease activity and severity may be confounded by non-pulmonary comorbidities. METHODS The(More)
  • A Caroline Heijckmann, Bianca Dumitrescu, Arie C Nieuwenhuijzen Kruseman, Piet Geusens, Bruce HR Wolffenbuttel, Jolanda De Vries +2 others
  • 2008
BACKGROUND Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be(More)
INTRODUCTION Clara cell protein 10 (CC-10) has been associated with inflammatory and infectious pulmonary diseases. This study evaluates CC-10 concentrations in bronchoalveolar lavage (BAL) fluid as a potential marker of ventilator-associated pneumonia (VAP). METHODS Between January 2003 and December 2007, BAL fluid samples obtained from critically ill(More)
PURPOSE The objective of the study was to systematically assess aortic inflammation in patients with granulomatosis with polyangiitis (GPA) using (18)F-2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) positron emission tomography (PET)/CT. METHODS Aortic inflammation was studied in PET/CT scans obtained from 21 patients with GPA; 14 patients with sarcoidosis were(More)
  • Rémy LM Mostard, Sander MJ Van Kuijk, Johny A Verschakelen, Marinus JPG van Kroonenburgh, Patty J Nelemans, Petal AHM Wijnen +1 other
  • 2012
BACKGROUND (18)F-FDG PET/CT (PET) is useful in assessing inflammatory activity in sarcoidosis. However, no appropriate indications are available. The aim of this study was to develop a prediction rule that can be used to identify symptomatic sarcoidosis patients who have a high probability of PET-positivity. METHODS We retrospectively analyzed a cohort of(More)
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