Global SUMOylation on active chromatin is an acute heat stress response restricting transcription
- E. Niskanen, Marjo Malinen, J. Palvimo
- BiologyGenome Biology
- 28 July 2015
HS-triggered SUMOylation targets promoters and enhancers of actively transcribed genes where it restricts the transcriptional activity of the HS-induced genes, likely to regulate Pol2-associated factors in HS.
SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin
- Sari Toropainen, Marjo Malinen, J. Palvimo
- BiologyNucleic Acids Research
- 30 December 2014
Androgen receptor (AR) is a ligand-activated transcription factor that plays a central role in the development and growth of prostate carcinoma. PIAS1 is an AR- and SUMO-interacting protein and a…
Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
- T. Degenhardt, Anna Saramäki, C. Carlberg
- BiologyJournal of Molecular Biology
- 14 September 2007
SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner
- P. Sutinen, Marjo Malinen, S. Heikkinen, J. Palvimo
- BiologyNucleic Acids Research
- 30 June 2014
Comparisons of androgen-regulated gene expression and AR chromatin occupancy in PC-3 prostate cancer cell lines stably expressing wild-type or doubly SUMOylation site-mutated AR indicate that SUMoylation regulates AR's interaction with the chromatin and the receptor's target gene selection.
Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells
- J. Lindqvist, Susumu Y. Imanishi, J. Eriksson
- BiologyMolecular Biology of the Cell
- 1 June 2015
CDK5 acts as a signaling hub in prostate cancer cells by controlling androgen responses through AR stabilization and specific gene targeting, maintaining and accelerating cell proliferation through…
Regulation of multiple insulin-like growth factor binding protein genes by 1α,25-dihydroxyvitamin D3
- Merja Matilainen, Marjo Malinen, Katri Saavalainen, C. Carlberg
- Biology, MedicineNucleic Acids Research
- 26 September 2005
Recently, insulin-like growth factor binding proteins (IGFBPs) have been found to be primary mediators of the anti-proliferative actions of the nuclear hormone 1α,25-dihydroxyvitamin D3…
Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to trichostatin A and 1α,25-dihydroxyvitamin D3
- Marjo Malinen, Anna Saramäki, A. Ropponen, T. Degenhardt, S. Väisänen, C. Carlberg
- Biology, ChemistryNucleic Acids Research
- 13 November 2007
The attenuation of the response to TSA by NCoR1 or that to 1α,25(OH)2D3 by HDACs can be overcome by their combined application achieving maximal induction of anti-proliferative target genes.
Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-κB cistrome to reprogram the prostate cancer cell transcriptome
- Marjo Malinen, E. Niskanen, M. Kaikkonen, J. Palvimo
- BiologyNucleic Acids Research
- 26 September 2016
Concomitant androgen and pro-inflammatory signaling significantly remodels especially the NF-κB cistrome, reprogramming the PC cell transcriptome in fashion that may contribute to the progression of PC.
In vivo transcriptome changes of human white blood cells in response to vitamin D
- A. Neme, Sabine Seuter, C. Carlberg
- Biology, MedicineJournal of Steroid Biochemistry and Molecular…
- 1 April 2019
Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling.
- Veli-Pekka Ronkainen, T. Tuomainen, P. Tavi
- Biology, ChemistryCardiovascular Research
- 2014
Cardiac expression of GPR35 is regulated by hypoxia through activation of HIF-1, and the expression of the gene in mouse models of cardiac infarction and pressure load suggests that it could be used as an early marker of progressive cardiac failure.
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