Marja van Kampen

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Agonists of α7 nicotinic acetylcholine receptors (nAChRs) may have therapeutic potential for the treatment of cognitive deficits. This study describes the in vitro pharmacology of the novel α7 nAChR agonist/serotonin 5-HT3 receptor (5-HT3R) antagonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141) and its behavioral effects. EVP-5141(More)
Animals exposed to stress are considered to be models for depression. In humans, stress is thought to initiate or exacerbate a number of psychiatric disorders such as post-traumatic stress syndrome or major depression. To improve our knowledge of the causal mechanisms of stress-related disorders, and to bridge the gap between experimental models and the(More)
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