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BACKGROUND The signaling cascades responsible for the activation of transcription factors in the hypertrophic growth of cardiac myocytes during hemodynamic overload are largely unknown. Several of the genes upregulated in the hypertrophied heart, including B-type natriuretic peptide (BNP) gene, are controlled by the cardiac-restricted zinc finger(More)
We examined whether adrenomedullin (AM), a vasoactive peptide with significant expression and binding sites in the heart, modulates the hypertrophic response in cultured neonatal rat ventricular myocytes. Myocyte hypertrophy was induced by treating the cells with angiotensin II (Ang II), endothelin-1 (ET-1) or alpha-adrenergic agonist, L-phenylephrine(More)
Adrenomedullin (AM) may function as an autocrine and/or paracrine factor in the heart, but the exact mechanisms regulating cardiac AM gene expression are unknown. The aim of the present study was to characterize the role of mechanical load in regulating gene expression of AM by using two hypertensive rat strains as experimental models. Acute pressure(More)
BACKGROUND To describe the rationale and design of the Northern Finland Birth Cohort (NFBC) Eye Study. METHODS The NFBC Eye Study is a randomised prospective cohort study. The original NFBC study population consists of 12058 subjects born in the region of Lapland and the Province of Oulu. A postal questionnaire covering extensively the medical and(More)
  • Alban L, Dahl Pj, +25 authors Gregersen H
  • 2006
Dominiczak AF (1999) Telemetry for cardiovascular monitoring in a pharmacological study. New approaches to data analysis. Nevalainen T. (2005) Comparison of and habituation to four common methods of handling and lifting of rats with cardiovascular telemetry. (2005) Altered brain stem responsivity to duodenal pain after a single stressful experience.(More)
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