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Carbonic anhydrases (CAs, EC are metalloenzymes which are ubiquitous in nature and are found in a variety of organisms. In mammals at least 16 different isozymes of CAs have been found. CAs catalyze the reversible hydration of carbon dioxide to bicarbonate with the release of protons. Abnormal levels and/or activities of these enzymes have been(More)
Sulfa drugs are well-known antibacterial agents containing N-substituted sulfonamide group on para position of aniline ring (NH2RSO2NHR'). In this study 2,4-dichloro-1,3,5-triazine derivatives of sulfa drugs, sulfamerazine (1b), sulfaquinoxaline (2b), sulfadiazine (3b), sulfadimidine (4b), and sulfachloropyrazine (5b) (1a-5a) were synthesized and(More)
In the mol-ecule of the title compound, C(18)H(18)N(2)O(5)S·H(2)O, the heterocyclic ring adopts a twisted conformation, while the aromatic rings are oriented at a dihedral angle of 45.46 (3)°. Intra-molecular C-H⋯O and N-H⋯O inter-actions result in the formations of planar five- and six-membered rings. In the crystal structure, N-H⋯O hydrogen bonds link the(More)
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