Marita McDonough

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OBJECTIVE To determine the effects of nevirapine (NVP), a nonnucleoside reverse-transcriptase inhibitor of HIV-1 and P450 inducer, on the pharmacokinetics (PK) of ethinyl estradiol (EE)/norethindrone (NET), a widely used oral contraceptive, and to assess the effects of EE/NET on the steady-state PK of NVP. METHODS Ten HIV-1-infected women underwent(More)
Age is often a determining factor in establishing a treatment program for these axial and angular problems. As can be seen, the deformities of torsion are noticeable from early life. Any tibial torsion should be treated early, but an excessive medial range of motion in the infant leg with a corresponding adequate lateral range of motion of the limb may be(More)
OBJECTIVE To examine the effect of 2 weeks of treatment with prednisone on the incidence of nevirapine-associated rash in HIV-1-infected patients receiving combination antiretroviral therapy. METHODS This was a 24-week, prospective, randomized, open-label, international study. Patients were randomized to receive nevirapine plus open-label prednisone (40(More)
A'séfiesof 21 carbamates and 8 aziridines were compared for quantitative carcinogenic activity using the pulmonary tumorinduction method in Strain A mice foi bîoassay. Aziridines as a class were more active than the carbamates, with 3,4-dichlorophertyl-jV-carbamoylaziridine being over 20 times more active on a molecular dose basis than urethan, the most(More)
injections of a 10% aqueous solution of ethyl carbamate (ure than), 1 mg/gm body weight. Groups of 3 mice were injected subcutaneously with thymi dine-methyl-3H (6.7 c/mmole), 25 per animal, at intervals of 1 to 21 days following urethan. The animals were killed by cervical dislocation 30 minutes after thymidine-3H and the lungs removed and fixed in(More)
whether the well-known fatty acids, the nutritional qualities and safety of which are taken for granted, have any car cinogenic effects. Not only are we interested in the carcinogenicity of oxidation products as described above, but, perhaps more important, we are searching for functional group-biological activity relationships. In this paper we report a(More)
A process evaluation of nurses' implementation of an infant-feeding counseling protocol was conducted for the Breastfeeding, Antiretroviral and Nutrition (BAN) Study, a prevention of mother-to-child transmission of HIV clinical trial in Lilongwe, Malawi. Six trained nurses counseled HIV-infected mothers to exclusively breastfeed for 24 weeks postpartum and(More)