Marisse K. Foronda

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The complement system is part of innate immunity and a link between innate and adaptive immunities. One of the functions of the complement system is tagging foreign pathogens by coating their surfaces with the protein C3b. The complement system discriminates “self” from “nonself” through tight regulation, which involves cleavage of C3b when it coats(More)
For systems involving highly and oppositely charged proteins, electrostatic forces dominate association and contribute to biomolecular complex stability. Using experimental or theoretical alanine-scanning mutagenesis, it is possible to elucidate the contribution of individual ionizable amino acids to protein association. We evaluated our electrostatic free(More)
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