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Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
Host recognition and immune-mediated foreign body response (FBR) to biomaterials can compromise the performance of implanted medical devices. To identify key cell and cytokine targets, here weExpand
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Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: one-year outcomes from the IMPROVE randomized trial
Aims To report the longer term outcomes following either a strategy of endovascular repair first or open repair of ruptured abdominal aortic aneurysm, which are necessary for both patient andExpand
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Impact of the Coronavirus (COVID-19) pandemic on surgical practice - Part 1
Abstract The Coronavirus (COVID-19) pandemic has resulted in over 2.3 million confirmed cases and over 160,000 deaths. The impact of COVID-19 on surgical practice is widespread ranging fromExpand
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Impact of the Coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation)
Abstract The Coronavirus (COVID-19) Pandemic represents a once in a century challenge to human healthcare with 2.4 million cases and 165,000 deaths thus far. Surgical practice has beenExpand
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Pancreatic and Biliary Secretion Differ in Cystic Fibrosis and Wild-Type Pigs
270* Neuroendocrine characterization of the intestine of F508del CFTR mice L. Hjelte1, M. Flodstrom-Tullberg2, A. Nilsson3, N. Wierup4, F. Sundler4. 1Karolinska Institutet, Karolinska Univ HospExpand
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Influence of foot ulceration on cause-specific mortality in patients with diabetes mellitus.
OBJECTIVE The purpose of this study was to assess the odds of all-cause mortality in individuals with diabetic foot ulceration (DFU) compared with those with diabetes and no history of DFU. InExpand
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Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways.
Pancreatic disease has onset in utero in humans with cystic fibrosis (CF), and progresses over time to complete destruction of the organ. The exact mechanisms leading to pancreatic damage in CF areExpand
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Pancreatic and biliary secretion are both altered in cystic fibrosis pigs.
The pancreas, liver, and gallbladder are commonly involved in cystic fibrosis (CF), and acidic, dehydrated, and protein-rich secretions are characteristic findings. Pancreatic function studies inExpand
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Long-Term Implant Fibrosis Prevention in Rodents and Non-Human Primates Using Localized Deliverable Crystals
Implantable medical devices have revolutionized modern medicine. However, immune-mediated foreign body response (FBR) to the materials of these devices can limit their function or even induceExpand
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