Mariska P Luttje

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This study presents quantified levels of phosphorylated metabolites in glandular tissue of human breast using (31)P magnetic resonance spectroscopy at 7 T. We used a homebuilt (1)H/(31)P radiofrequency coil to obtain artifact-free (31)P MR spectra of glandular tissue of healthy females by deploying whole breast free induction decay (FID) detection with(More)
The measurement of full metabolic profiles at ultrahigh fields including low concentrated or fast-relaxing metabolites is usually achieved by applying short echo time sequences. One sequence beside stimulated echo acquisition mode that was proposed in this regard is spin echo full intensity-acquired localized spectroscopy. Typical problems that are still(More)
PURPOSE Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both (1) H and (31) P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer. METHODS A two-element(More)
PURPOSE Hypoxia is an important marker for resistance to therapy. In this study, we quantify the macroscopic effects of R2* mapping in prostate cancer patients incorporating susceptibility matching and field strengths effects. MATERIALS AND METHODS 91 patients were scanned without endorectal coil (ERC) at 3T. Only when rectal gas was absent, data was(More)
Higher magnetic field strengths, such as 7 T, offer increased spectral resolution and higher signal-to-noise ratio. These properties can be very advantageous for MRSI. In particular, signals that generally overlap at lower fields, such as choline, polyamines and creatine, can be resolved at 7 T. However, higher magnetic field strengths suffer from strong(More)
Spectral degradations as a result of temporal field variations are observed in MRSI of the human prostate. Moving organs generate substantial temporal and spatial field fluctuations as a result of susceptibility mismatch with the surrounding tissue (i.e. periodic breathing, cardiac motion or random bowel motion). Nine patients with prostate cancer were(More)
The increased magnetic susceptibility effects at higher magnetic fields increase the demands for shimming of the B0 field for in vivo MRI and MRS. Both static and dynamic techniques have been developed to compensate for susceptibility-induced field inhomogeneities. In this study, we investigate the impact of and need for both static and dynamic higher order(More)
M. P. Luttje, M. Wyss, N. Zölch, A. Fuchs, R. A. Edden, S. Heinzer, P. Bösiger, and A. Henning Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Zurich, Switzerland, Contributed equally, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States,(More)
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