Marisa A. Leal

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A central hypothesis for the limited capacity for adult central nervous system (CNS) axons to regenerate is the presence of myelin-derived axon growth inhibitors, the role of which, however, remains poorly understood. We have conducted a comprehensive genetic analysis of the three major myelin inhibitors, Nogo, MAG, and OMgp, in injury-induced axonal(More)
BACKGROUND Stromal derived factor-1α (sdf-1α), a chemoattractant chemokine, plays a major role in tumor growth, angiogenesis, metastasis, and in embryogenesis. The sdf-1α signaling pathway has also been shown to be important for somite rotation in zebrafish (Hollway et al., 2007). Given the known similarities and differences between zebrafish and Xenopus(More)
The alpha-subunit of the heterotrimeric G-protein, G12, has been shown to induce cellular transformation when overexpressed or oncogenically activated in rodent fibroblasts. To investigate the interaction between Galpha12 transforming pathway and the Ras-Raf-MAPK pathway, we examined the ability of mitogenic signaling molecules in cooperating with Galpha12(More)
Stromal derived factor-1α (Sdf-1α), a chemoattractant chemokine, along with its exclusive receptor CXCR4, plays a major role in tumor growth, angiogenesis, metastasis and in development. Recently, the Sdf-1α signaling pathway was shown to be important for zebrafish somitogenesis (Holloway, et al 2007). Somitogenesis is an important embryological process as(More)
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