JunD regulates genes involved in antioxidant defence. We took advantage of the chronic oxidative stress resulting from junD deletion to examine the role of reactive oxygen species (ROS) in tumour development. In a model of mammary carcinogenesis, junD inactivation increased tumour incidence and revealed an associated reactive stroma. junD-inactivation in… (More)
Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potential therapeutic targets, we searched for protein kinases that are overexpressed in human TNBC biopsies and… (More)
This paper outlines the setting up of a new service in primary care offering acupuncture to patients with severe osteoarthritis of the knee. The high volume clinic is funded under the Practice Based Commissioning initiative and is the first of its type in the UK. It appears to offer a model for similar services elsewhere.
BACKGROUND Acupuncture has been provided in nurse-led group clinics in St Albans since 2008. It is funded by a commissioning group within the National Health Service, on a trial basis, for patients with knee osteoarthritis who would otherwise be referred to an orthopaedic surgeon. AIM To evaluate the patients seen in the service's first year of operation… (More)
Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMs). In this study, we characterized the stroma in various models of breast cancer tumors in mice. We performed transcriptomic and flow… (More)
PURPOSE (1) To determine TweakR expression in human breast cancers (BC), (2) evaluate the antitumor effect of the anti-TweakR antibody PDL192, used alone or after chemotherapy-induced complete remission (CR), on patient-derived BC xenografts (PDX) and (3) define predictive markers of response. EXPERIMENTAL DESIGN TweakR expression was analyzed by IHC on… (More)
This article is the first in a four-part series on hearing and balance, continuing our exploration of the senses. It discusses the outer and middle chambers of the ear, whose primary function is to transmit sound to the auditory receptors in the inner ear (Allan, 2005).
Editors Note: On Monday evening, June 2, 1985 following the annum banquet of the Psycho-metric Society in Nashville, TN, Lyle Jones moderated a discussion with two of the three living founders of the Society, Paul Horst and John Stalnaker. Albert Kurtz planned to attend, but a recent automobile accident prevented him from traveling. They commented upon the… (More)