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—Several recent publications have shown that joint source-channel decoding could be a powerful technique to take advantage of residual source redundancy for fixed-and variable length source codes. This letter gives an in-depth analysis of a low-complexity method recently proposed by Guivarch et al., where the redundancy left by a Huffman encoder is used at(More)
Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As2O3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARalpha (a(More)
Mechanical forces including gravity affect endothelial cell (ECs) function, and have been implicated in vascular disease as well as physiologic changes associated with low gravity environments. The goal of this study was to investigate the impact of gravitational mechanical unloading on ECs phenotype as determined by patterns of gene expression. Human(More)
Ammonium (NH4+ and/or NH3) and K+ are released from active neurons and taken up by glial cells, and can modify glial cell behaviour. Study of these fluxes is most advanced in the retina of the honeybee drone, which consists essentially of identical neurons (photoreceptors) and identical glial cells (outer pigment cells). In isolated bee retinal glial cells,(More)
OBJECTIVE Mutations in the type IV collagen alpha 1 gene (COL4A1) cause dominantly inherited cerebrovascular disease. We seek to determine the extent to which COL4A1 mutations contribute to sporadic, nonfamilial, intracerebral hemorrhages (ICHs). METHODS We sequenced COL4A1 in 96 patients with sporadic ICH. The presence of putative mutations was tested in(More)
Several recent publications have shown that joint source-channel decoding (JSCD) could be a powerful technique for taking advantage of residual source redundancy. Furthermore, it appeared that the principle could also be successfully applied to variable length codes (VLCs). This paper gives an in-depth analysis of a new method recently proposed in [1], [2](More)
The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are stress-responsive domains where many partner proteins accumulate. Here, we clarify the basis for NB formation and identify stress-induced partner sumoylation as the primary NB function. NB nucleation does not rely primarily on intermolecular interactions between the PML(More)
Collagen type IV alpha 1 and 2 (COL4A1 and COL4A2) are present in nearly all basement membranes. COL4A1 and COL4A2 mutations are pleiotropic, affecting multiple organ systems to differing degrees, and both genetic-context and environmental factors influence this variable expressivity. Here, we report important phenotypic and molecular differences in an(More)
This paper describes the application of a joint source channel decoding technique (JSCD) of variable length codes (VLCs), presented at first by Guiv-arch et al., in the context of future public land mobile telecommunication systems (FPLMTS) involving UMTS channel codes and OFDM modulation. OFDM parameter sets have been adjusted both to the UMTS chip rate(More)