Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency.

• Marion Bouchecareilh, Darren M. Hutt, Patricia Szajner, Terence R. Flotte, William Edward Balch
• The Journal of biological chemistry
• 2012

α1-Antitrypsin (α1AT) deficiency (α1ATD) is a consequence of defective folding, trafficking, and secretion of α1AT in response to a defect in its interaction with the endoplasmic reticulum… (More)

Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis.

• Arisa Higa, Audrey Mulot, +5 authors Eric Chevet
• The Journal of biological chemistry
• 2011

The protein-disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) is reportedly overexpressed in numerous cancers and plays a role in cancer development. However, to date the molecular… (More)

Proteostasis, an emerging therapeutic paradigm for managing inflammatory airway stress disease.

• Marion Bouchecareilh, William Edward Balch
• Current molecular medicine
• 2012

Airways stress diseases (ASDs), including chronic obstructive pulmonary disease (COPD), emphysema and asthma, are predicted to become the third leading cause of morbidity and mortality by 2020. An… (More)

Proteostasis: a new therapeutic paradigm for pulmonary disease.

• Marion Bouchecareilh, William Edward Balch
• Proceedings of the American Thoracic Society
• 2011

Among lung pathologies, α1AT, chronic obstructive pulmonary disease (COPD), emphysema, and asthma are diseases triggered by local environmental stress in the airway that we refer to herein… (More)

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

• Daniela Roth, Darren M. Hutt, +10 authors William Edward Balch
• PLoS biology
• 2014

Diseases of protein folding arise because of the inability of an altered peptide sequence to properly engage protein homeostasis components that direct protein folding and function. To identify… (More)

Proteostasis strategies for restoring alpha1-antitrypsin deficiency.

• Marion Bouchecareilh, Juliana Johnson Conkright, William Edward Balch
• Proceedings of the American Thoracic Society
• 2010

The function of the human proteome is defined by the proteostasis network (PN) (Science 2008;319:916; Science 2010;329:766), a biological system that generates, protects, and, where necessary,… (More)

• ‹
• 1
• ›