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Arterial inflammation is the consequence of an orchestrated response of cells within the arterial wall to multifactorial modes of injury; arterial inflammation is a fundamental mechanism contributing to atherosclerosis and restenosis. The re-modeling of the arterial wall that results from the inflammation could either be obstructive (as in coronary and(More)
Identification of the direct spinal areas (portions of the dorsal and medial accessory nuclei) within the opossum inferior olivary complex was accomplished by mapping the location of the terminal degeneration by the Fink-Heimer technique subsequent to cervical cord lesions. Following similar lesions, sampling of these same regions for electron microscopic(More)
Previous studies have shown that the bacterial exoenzyme phospholipase C permanently alters the chemical structure of erythrocyte ghosts. The present investigation has shown some of the functional, chemical and structural changes that sequentially occur when intact human red blood cells are lysed by this enzyme. Following exposure to the enzyme, membrane(More)
Phospholipase C fromBacillus cereus was used as a tool for the study of membrane structure. Interference and electron microscopic examination of isolated rat kidney mitochondria and human red blood cell ghosts incubated in the presence of the enzyme revealed that there were discrete areas of digestion on the membranes. These areas were distributed over the(More)
Atherosclerosis is mediated by local and systematic inflammation. The multiligand receptor for advanced glycation end products (RAGE) has been studied in animals and humans and is an important mediator of inflammation and atherosclerosis. This review focuses on S100/calgranulin proteins (S100A8, S100A9, and S100A12) and their receptor RAGE in mediating(More)
BACKGROUND Cardiovascular disease including left ventricular hypertrophy, diastolic dysfunction and ectopic valvular calcification are common in patients with chronic kidney disease (CKD). Both S100A12 and fibroblast growth factor 23 (FGF23) have been identified as biomarkers of cardiovascular morbidity and mortality in patients with CKD. We tested the(More)
Airway inflammation, lung remodeling, and Airway Hyperresponsiveness (AHR) are major features of asthma and Chronic Obstructive Pulmonary Disease (COPD). The inflammatory response to allergens, air pollutants, and other insults is likely to play a key role in promoting structural changes in the lung including the overabundance of Airway Smooth Muscle (ASM)(More)
W ith an estimated 17.5 million deaths yearly, cardiovas-cular diseases remain the leading cause of death in the world. 1 Atherosclerosis is a chronic inflammatory process of the vascular wall mediated by activated macrophages, T lym-phocytes, B lymphocytes, and smooth muscle cells (SMC). Accordingly, multiple inflammatory serum markers have been(More)
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