Mario V. Capparelli

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The crystal structures of five 1, 4-dihydro-2, 3-quinoxalinediones, antagonists of the NMDA modulatory glycine binding site on the excitary amino acid (EAA) receptor complex, have been determined: (I) 6, 7-dinitro-1, 4-dihydro-2, 3-quinoxalinedione (DNQX); (II) 5, 7-dinitro-1,4-dihydro-2, 3-quinoxalinedione (MNQX); (III) 6-nitro-1,4-dihydro-2,(More)
The design and synthesis of novel sterol hydrazone analogues (9, 10, 11 and 12) are described, followed by their evaluation as inhibitors of fungal growth, using Paracoccidioides brasiliensis as the biological tester. Compounds 9, 10, 11 and 12 generated a dose-dependent effect in fungal growth, particularly 9, 11 and 12, which were active at nanomolar(More)
An improved procedure for the synthesis of 3-amino-9-arylsubstituted-thieno[3,2-b]benzothiazine S,S-dioxide 2-decarboxylated is reported. Thieno-[3,2-b]benzothiazine S,S-dioxide derivatives were investigated for their abilities to inhibit beta-hematin formation, hemoglobin hydrolysis and in vivo for their efficacy in rodent Plasmodium berghei. Compounds(More)
A series of phenylsubstituted pyrazolo and pyrimido benzothiazine dioxide derivatives were synthesized and investigated for their abilities to inhibit beta-hematin formation, hemoglobin hydrolysis and in vivo for their antimalarial efficacy in rodent Plasmodium berghei. Compounds 3-amino-7-chloro-9-(2'-methylphenyl)-1,9-dihydro-pyrazolo-[4,3-b]benzothiazine(More)
The title compound, C(10)H(11)NTe, is the first organyl ethynyl telluride, R-Te-C C-H, to be structurally characterized. In the L-shaped mol-ecule, the aryl moiety, viz. Me(2)NC(6)H(4)Te, is almost perpendicular to the Te-C C-H fragment. The Te-Csp(2) bond [2.115 (3) Å] is significantly longer than the Te-Csp bond [2.041 (4) Å]. The Te-C C group is(More)
A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both(More)
Green crystals of the title compound, C(14)H(14)I(2)O(2)Te x 0.5 C(2)H(6)OS, space group P3(2), show twinning by merohedry (class II). The asymmetric unit contains two organotellurium molecules and one dimethyl sulfoxide (DMSO) molecule. The crystal structure displays secondary Te...I and Te...O(DMSO) bonds that lead to [(4-MeOC(6)H(4))(2)TeI(2)](2) x DMSO(More)
In the title compound, [Cu(C(10)H(8)N(2))(C(18)H(15)P)(2)]NO(2)·CHCl(3)·0.5H(2)O, the Cu atom is tetra-hedrally coordinated by a bidentate 2,2'-bipyridine ligand and two PPh(3) ligands. The Cu-N and Cu-P distances are similar to those observed in similar compounds. The range of coordination angles shows a moderate distortion from ideal tetra-hedral(More)
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