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In order to extract quantitative parameters from PET images, several physical effects such as photon attenuation, scatter, and partial volume must be taken into account. The main objectives of this work were the evaluation of photon attenuation in small animals and the implementation of two attenuation correction methods based on X-rays CT and segmentation(More)
In this work we developed a Monte Carlo (MC) model of the Sedecal Argus pre-clinical PET scanner, using GATE (Geant4 Application for Tomographic Emission). This is a dual-ring scanner which features DOI compensation by means of two layers of detector crystals (LYSO and GSO). Geometry of detectors and sources, pulses readout and selection of coincidence(More)
The goal of this work was to improve the image quality of small animal PET images by introducing in the reconstruction process the true system point spread function (PSF) and an anatomical image prior. Simulations were performed using a mouse heart phantom (myocardium and ventricles) and a comparison between standard EM reconstruction and EM with PSF(More)
Small animal positron emission tomography (PET) image quantitation is severely affected by partial volume effect (PVE) caused by the spatial resolution of PET tomo-graphs. The aim of this work was to reduce the PVE using a modified iterative expectation maximization (EM) reconstruction algorithm. The goal of the method was to increase the accuracy of tracer(More)
A method for partial volume correction of positron emission tomography (PET) images is proposed. The method is based on combining information from PET and high resolution anatomical images. Two different algorithms fast wavelet transform andà trous were implemented in order to decompose the PET and high resolution images. Results obtained using several(More)
Positron emission tomography (PET) is a non-invasive imaging modality, which is clinically widely used both for diagnosis and accessing therapy response in oncology, cardiology and neurology.Fusing PET and CT images in a single dataset would be useful for physicians who could read the functional and the anatomical aspects of a disease in a single shot.The(More)
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