Mario Lucio de Sousa

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Breast cancer is the most common cancer of women worldwide. Its frequency increases throughout the female lifespan. Epidemiological research has clearly identified important reproductive risk factors for breast cancer, including age at menarche, age at menopause, age at first-term pregnancy and nulliparity, which provide important clues to the hormonal(More)
Regucalcin (RGN) is a calcium (Ca(2+))-binding protein which plays an important role in the regulation of Ca(2+) homeostasis and has been shown to catalyse an important step in L-ascorbic acid biosynthesis. It is encoded by an X-linked gene and differs from other Ca(2+)-binding proteins by lacking the typical EF-hand Ca(2+)-binding domain. RGN controls(More)
OBJECTIVE To study the expression and localization of Aven in rat and human testis from azoospermic patients with different etiologies and its regulation by estrogens. DESIGN Experimental study. SETTING University research center and private IVF clinic. PATIENT(S) Six men with obstructive azoospermia, five with hypospermatogenesis, and six with(More)
There is no doubt that nowadays the menopause is in crisis [1]. The misinterpretation of the results of recent epidemiological studies (HERS, WHI, MWS) by the media and by a great majority of the medical profession has casted many doubts about the validity of hormonal treatments during the menopausal transition and beyond. This has alarmed many women who(More)
INTRODUCTION Creativity is a complex human ability influenced by affective and cognitive components but little is known about its underlying neurobiology. Bipolar Disorder (BD) is highly prevalent among creative individuals. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophic factor, and has been implicated in the(More)
When developing applications with high integrity requirements, the choice of programming language is of utmost importance. In fact, IEC 61508 includes a table with suggested programming languages for each SIL (safety integrity level). The languages defined in IEC 61131-3 are included in this table, but are only highly recommended for the higher SILs if a(More)
Being distributed in nature, IEC 61499 industrial control applications are subject to partial failures. Building applications that are tolerant of these failures (i.e. a fault-tolerant application) may be achieved through the use of replication. In this paper we present a framework to support replicated IEC 61499 applications, and study how replica(More)
During the development of a new parser for the grammar defined in the latest edition of IEC 61131-3, the authors came across many inconsistencies between the main body of the standard and the formal definition of the grammar. This paper explains the inconsistencies that were uncovered, and suggests corrections to the formal grammar.
In the last years many standards have been created for the industrial control domain. Some have found wide adoption in the industry, while others seem to never leave the stage of a promising technology. An example of the first type is ISA 88, that defines an architectural design for control applications for the batch process industry. The author is of the(More)