Mario I. Romero-Ortega

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Cumulative evidence from both humans and animals suggests that the anterior cingulate cortex (ACC) is important for pain-related perception, and thus a likely target for pain relief therapy. However, use of existing electrode based ACC stimulation has not significantly reduced pain, at least in part due to the lack of specificity and likely co-activation of(More)
The brain is an enormously complex organ structured into various regions of layered tissue. Researchers have attempted to study the brain by modeling the architecture using two dimensional (2D) in vitro cell culturing methods. While those platforms attempt to mimic the in vivo environment, they do not truly resemble the three dimensional (3D) microstructure(More)
The integration of newborn neurons into functional neuronal networks requires migration of cells to their final position in the developing brain, the growth and arborization of neuronal processes and the formation of synaptic contacts with other neurons. A central player among the signals that coordinate this complex sequence of differentiation events is(More)
A biocompatible neural microprobe constructed using well-established SU-8 microfabrication techniques is described that was designed to record fiber spike signals from regenerated axons within peripheral nerves. These microprobes features bipolar longitudinal gold electrodes recessed below the surface within “grooves” designed to guide the growth of(More)
Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed sub-modality types, which difficult the specific recording from motor axons and the eliciting of precise sensory modalities through selective(More)
In the injured adult nervous system, re-establishment of growth-promoting molecular gradients is known to entice and guide nerve repair. However, incorporation of three-dimensional chemotactic gradients in nerve repair scaffolds, particularly in those with multi-luminal architectures, remains extremely challenging. We developed a method that establishes(More)
1 Department of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, Medical School Teaching Facility 559 A, Baltimore, MD 21201, USA 2Department of Biomedical Engineering, Physical Medicine & Rehabilitation, Anesthesiology & Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA 3Department of Bioengineering,(More)
Loosing motor activity due to impaired or damaged nerves or muscles affects millions of people world-wide. The resulting lack of mobility and/or impaired communication bears enormous personal, economical and social costs. While several assistive technologies exist, they rely on device surrogates to compensate for the lack of movement and thus provide(More)
Wireless stimulation of neural tissue could enable many emerging neural prosthesis designs, and eliminate problems associated with percutaneous wires and connectors. Our laboratory has developed a 16-channel wireless floating microelectrode array (WFMA) for chronic implantation. Here, we report on its first use within in-vivo experiments, using a rat(More)
INTRODUCTION Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function after PNI. METHODS We developed an(More)