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BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX), which leads to suppression of COX-1-mediated production of gastrointestinal-protective prostaglandins. Gastrointestinal injury is a common outcome. We compared the efficacy, safety, and tolerability of long-term therapy with celecoxib, a COX-1 sparing inhibitor of(More)
The possible role of Saccharomyces boulardii, a nonpathogenic yeast with beneficial effects on the human intestine, in the maintenance treatment of Crohn’s disease has been evaluated. Thirty-two patients with Crohn’s disease in clinical remission (CDAI < 150) were randomly treated for six months with either mesalamine 1 g three times a day or mesalamine 1 g(More)
OBJECTIVE Transdermal nicotine appears to be of benefit in the short-term treatment of patients with ulcerative colitis. The aim of this study was to determine its long-term effects. DESIGN A randomized, comparative study. PATIENTS AND METHODS Patients with mild to moderate clinical relapses of left-sided ulcerative colitis during maintenance treatment(More)
Intestinal bacteria play a role in the development of non-steroidal anti-inflammatory drugs (NSAID)-induced small intestinal injury. Agents such as probiotics, able to modify the gut ecology, might theoretically be useful in preventing small intestinal damage induced by NSAIDs. The clinical studies available so far do suggest that some probiotic agents can(More)
  • M Guslandi
  • 1996
NSAIDs are among the most frequently prescribed drugs worldwide. Unfortunately acute and especially chronic NSAID intake is accompanied by untoward side effects of the digestive system, particularly the gastroduodenal tract. Erosions and ulcers are more common in the stomach, but also the duodenal mucosa can be involved. Elderly patients are the subjects(More)
OBJECTIVES Probiotics can be useful in the treatment of inflammatory bowel disease. In a previous report, the non-pathogenic yeast Saccharomyces boulardii was found to be beneficial in the maintenance treatment of Crohn's disease. The aim of this study was to assess the efficacy of S. boulardii in ulcerative colitis patients. METHODS A group of 25(More)
BACKGROUND It has been speculated that midazolam may be effective in reducing the required dose of propofol during sedation. AIM To evaluate the sparing effect of midazolam during target-controlled propofol infusion. METHODS Two hundred-seventy patients undergoing upper endoscopic ultrasound were randomised to receive sedation with propofol plus placebo(More)