Mario Guanziroli

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The X-ray crystal structure of the ferric sperm whale (Physeter catodon) myoglobin:imidazole complex has been refined at 2.0 A resolution, to a final R-factor of 14.8%. The overall conformation of the protein is little affected by binding of the ligand. Imidazole is co-ordinated to the heme iron at the distal site, and forces distinguishable local changes(More)
P1 Inhibition of jak/stat3 signaling pathway by small molecule r548 prevents inflammation in experimental murine lung injury model V. Karavana, I. Smith, G. Kanellis, I. Sigala, T. Kinsella, S. Zakynthinos George P. Livanos and Marianthi Simou Laboratories, Athens, Greece; Rigel Pharmaceuticals, Inc, South San Francisco, CA, USA; Evangelismos Hospital,(More)
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