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BACKGROUND Although the mouse is the animal model most widely used to study the pathogenesis and treatment of human diseases, reference values for biochemical parameters are scanty or lacking for the most frequently used strains. We therefore evaluated these parameters in the C57BL/6J, 129SV/EV and C3H/HeJ mice. METHODOLOGY/PRINCIPAL FINDINGS We measured(More)
The phosphorylation of thyroid transcription factor-1 (TTF-1), is homeodomain-containing transcription factor that is required for thyroid-specific expression of the thyroglobulin and thyroperoxidase gene promoters, has been studied. Phosphorylation occurs on a maximum of seven serine residues that are distributed in three tryptic peptides. Mutant(More)
—Inter-vehicle communications will play an important role in future cars and traffic management in general. Many different services have been proposed in the literature using vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications. These services include safety applications like collision warning, up-to-date traffic information, active(More)
Vehicular Ad-Hoc Networks (VANETs) will play an important role in Smart Cities and will support the development of not only safety applications, but also car smart video surveillance services. Recent improvements in multimedia over VANETs allow drivers, passengers, and rescue teams to capture, share, and access on-road multimedia services. Vehicles can(More)
—A key paradigm enabled by Vehicular Ad hoc NETworks is the support of location aware push-mode info-tainment services, besides the safety services that motivate the deployment of the technology in the first place. Message and advertisements are spread via multi-hop communications from the originating Road Side Units connected to the Internet. Support of(More)
BACKGROUND The transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified by phosphorylation. We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation. RESULTS(More)
The thyroid and lungs originate as neighboring bud shaped outgrowths from the midline of the embryonic foregut. When and how organ specific programs regulate development into structures of distinct shapes, positions and functions is incompletely understood. To characterize, at least in part, the genetic basis of these events, we have employed laser capture(More)
The generation of pancreatic endocrine and exocrine functional precursors from embryonic stem cells (ESCs) is an intriguing opportunity to address cell therapy challenges. The main goal of cellular regeneration is to derive, in vitro, pancreatic progenitor cells (PPCs) that retain the capacity to differentiate following the in vivo developmental ontogeny.(More)
Dicer is a crucial enzyme for the maturation of miRNAs. Mutations in the Dicer gene are highly associated with Pleuro Pulmonary Blastoma-Family Dysplasia Syndrome (PPB-FDS, OMIM 601200), recently proposed to be renamed Dicer syndrome. Aside from the pulmonary phenotype (blastoma), renal nephroma and thyroid goiter are frequently part of Dicer syndrome. To(More)
BACKGROUND The molecular mechanisms leading to a fully differentiated thyrocite are still object of intense study even if it is well known that thyroglobulin, thyroperoxidase, NIS and TSHr are the marker genes of thyroid differentiation. It is also well known that Pax8, TTF-1, Foxe1 and Hhex are the thyroid-enriched transcription factors responsible for the(More)