Mario Cools

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We have cloned a human Hevin cDNA from omental adipose tissue of different patients by reverse transcription polymerase chain reaction and shown a sequence variation due to a possible polymorphism at amino acid position 161 (E/G). Hevin protein expressed in vitro showed molecular weights of approximately 75 kDa and 150 kDa, suggesting that Hevin may form a(More)
BACKGROUND Randomized trials have confirmed the efficacy of prucalopride for the treatment of chronic constipation up to 12 weeks. This study aimed to assess the efficacy of prucalopride over a 24-week period ( NCT01424228). METHODS Adults with chronic constipation and ≤2 spontaneous complete bowel movements (SCBMs)/week were randomized(More)
BACKGROUND Gastroparesis is a chronic gastric disorder characterized by delayed gastric emptying without mechanical obstruction, and clinical symptoms as postprandial fullness, early satiety, bloating, nausea, vomiting, and abdominal pain. Prokinetic agents are used for the treatment of gastroparesis. Revexepride, a 5-hydroxytryptamine (serotonin) receptor(More)
Few studies have examined the impact of androgen insensitivity on human spatial learning and memory. In the present study, we tested 11 women with complete androgen insensitivity syndrome (CAIS), a rare genetic disorder characterized by complete absence of AR activity, and compared their performance against 20 comparison males and 19 comparison females on a(More)
Urban development is a complex process influenced by a number of driving forces, including spatial planning, topography and urban economics. Identifying these drivers is crucial for the regulation of urban development and the calibration of predictive models. Existing land-use models generally consider urban development as a binary process, through the(More)
Keywords: Profile Hidden Markov Models (pHMMs) Sequence Alignment Methods (SAM) Multiple sequence alignments Activity sequences Activity-travel diaries Mobile phone data a b s t r a c t In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the(More)
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