Mario Bermúdez de León

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In 2000, Costa Rica set a goal for accelerated rubella control and congenital rubella syndrome (CRS) prevention in conjunction with its established measles eradication goal. To achieve this goal, a National Plan of Action for the integration of a measles-rubella (MR) vaccination strategy was implemented. The components of the national plan included(More)
Mycobacterium tuberculosis has developed resistance to anti-tuberculosis first-line drugs. Multidrug-resistant strains complicate the control of tuberculosis and have converted it into a worldwide public health problem. Mutational studies of target genes have tried to envisage the resistance in clinical isolates; however, detection of these mutations in(More)
Objective To assess the effectiveness and functional capacity with rheumatoid artritis treated with biologic after dose reduction. Methods A retrospective study on a cohort of 13 patients diagnosed rheumatoid artritis treated with anti-TNF (10 patients with etanercept, and 3 with adalimumab) and clinical remission (DAS28 < 2.6) in the last 6 mounths, in(More)
To study the effect of DM1-associated CTG repeats on neuronal function, we developed a PC12 cell-based model that constitutively expresses the DMPK gene 3′-untranslated region with 90 CTG repeats (CTG90 cells). As CTG90 cells exhibit impaired neurite outgrowth and as microtubule-associated proteins (MAPs) are crucial for microtubule stability, we analyzed(More)
It is well known that many engineering students, mainly freshmen have a lack of team work and effective communication skills. It is also apparent that the amazing development of multimedia computer software and communication technologies have made more evident those weaknesses and, at the same time, have shown that many freshman students need to be trained,(More)
Objective To assess the clinical and economic efficiency as well as functional capacity in patients with rheumatoid artritis treated with biologic after dose reduction. Methods A retrospective study on a cohort of 13 patients diagnosed rheumatoid artritis (RA) treated with anti-TNF (10 patients with etanercept, and 3 with adalimumab) and clinical remission(More)
Objective To evaluate the clinical and functional activity of patients with rheumatoid arthritis at one and two years after starting anti-TNF therapy. This is a retrospective study of 50 RA patients, who started ANTI-TNF theraphy between June 2006 and july 2009. The main variables in the study were: DAS28, HAQ and pain VAS. We analyzed evolution after 1(More)
The object of this work was to determine the efficacy of a low range International Normalized Ratio (INR) between 1.5 and 1.9, in preventing recurrent venous thrombosis and the hemorrhagic manifestations that can complicate anticoagulation with warfarin. Thirty nine patients, 10 to 78 years of age were studied between January 2006 and November 2009. All of(More)
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