Mario Alberto Mireles-Ramírez

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system associated with demyelination and axonal loss eventually leading to neurodegeneration. MS exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB). The BBB is a complex organization of cerebral endothelial cells,(More)
Molecular oxygen is essential for aerobic organisms in order to synthesize large amounts of energy during the process of oxidative phosphorylation and it is harnessed in the form of adenosine triphosphate, the chemical energy of the cell. Oxygen is toxic for anaerobic organisms but it is also less obvious that oxygen is poisonous to aerobic organisms at(More)
OBJECTIVE The present study was specifically designed to discern the possible existence of subgroups of patients with the relapsing-remitting form of multiple sclerosis (RRMS) depending on their gender, age, disease stage (relapsing or remitting), time of disease evolution and response to different treatments. METHODS We analyzed samples from patients(More)
Genaro Gabriel Ortiz1*, Luis Javier Flores-Alvarado2, Fermín Paul Pacheco-Moisés3, Mario A. Mireles-Ramírez4, Erika Daniela GonzálezRenovato1, Angélica Lizbeth Sánchez-López1, Lorenzo Sánchez-Romero1, Juan Francisco Santoscoy1, Irma E. Velázquez Brizuela1 and Víctor J Sánchez-González5 1Laboratorio Desarrollo-Envejecimiento; Enfermedades Neurodegenerativas.(More)
Objective To determine the effect of melatonin (MEL) administration on ciclooxigenase 2 (COX-2) activity and serum concentration of nitric oxide metabolites, lipoperoxides and glutathione peroxidase (GPx) activity in patients with Parkinson's disease. Methods Prospective double-blind randomized clinical pilot trial. 13 patients were included and two(More)
The CD40/CD40L system is a binding key for co-stimulation of immune cells. Soluble form of CD40L has been widely studied as marker of inflammatory and autoimmune diseases. Here we analyze serum concentrations of sCD40L, as well as 14 cytokines, in patients with Multiple Sclerosis (MS) treated with Glatiramer acetate or Interferon beta. In the healthy(More)
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