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Oncology drug development has seen a paradigm shift in the past decade from traditional cytotoxic agents to molecular targeted therapies. Given the different mechanisms and toxicities of theseContinue Reading
The Methodology for the Development of Innovative Cancer Therapies (MDICT) task force considered aspects of the design and conduct of phase II studies for molecular targeted agents during their 2007Continue Reading
  • Shivaani Kummar, James H. Doroshow, Joseph E. Tomaszewski, Alan Hilary Calvert, Marinus W Lobbezoo, Giuseppe Giaccone
  • Medicine
  • European journal of cancer
  • 2009 (First Published: 1 March 2009)
  • The Methodology for the Development of Innovative Cancer Therapies (MDICT) task force has been established as an expert forum to develop practical guidance on the development of innovative anticancerContinue Reading
  • Stephen V Liu, Vincent A. Miller, Marinus W Lobbezoo, Giuseppe Giaccone
  • Medicine
  • European journal of cancer
  • 2014 (First Published: 1 November 2014)
  • The Methodology for the Development of Innovative Cancer Therapies (MDICT) task force discussed incorporation of genomic profiling into early (Phase I and II) clinical trials in oncology. The taskContinue Reading
  • Lesley K Seymour, Alan Hilary Calvert, Marinus W Lobbezoo, Elizabeth A. Eisenhauer, Giuseppe Giaccone
  • Medicine
  • European journal of cancer
  • 2013 (First Published: 1 May 2013)
  • The Methodology for the Development of Innovative Cancer Therapies (MDICT) task force considered aspects of the design and conduct of early (phase I and II) studies of combinations of molecularContinue Reading
  • Marinus W Lobbezoo, Alan Hilary Calvert, Elizabeth A. Eisenhauer, Giuseppe Giaccone
  • Medicine
  • 2012 (First Published: 1 February 2012)
  • The Task Force on Methodology for the Development of Innovative Cancer Therapies is an expert forum established to discuss methodological issues in the early clinical development of newContinue Reading