Marina V Sysoeva

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PURPOSE Spike and wave discharges (SWDs), generated within cortico-thalamo-cortical networks, are the electroencephalographic biomarker of absence epilepsy. The current work aims to identify mechanisms of SWD initiation, maintenance and termination by the analyses of dynamics and directionality of mutual interactions between the neocortex and various(More)
The extraction and purification of a zein were carried out by a method described previously [3]. Since the separation of zein in the alkaline pH region by the IEF method in Ultrodex according to [2] proved to be difficult, for fractionating the polypeptides IEF was performed in 3.5% PAAG containing 6.5 M urea and 2% of ampholines on a 12 x 26 cm horizontal(More)
Generalized spike and wave discharges (SWDs) are generated within the cortico-thalamo-cortical system, being an electroencephalographic sign of absence epilepsy. The current work aims to identify mechanisms of SWD initiation, maintenance and termination. Dynamics and directionality of mutual interactions between neocortex (occipital (OC) and frontal (FC)(More)
BACKGROUND Advanced methods of signal analysis of the preictal and ictal activity dynamics characterizing absence epilepsy in humans with absences and in genetic animal models have revealed new and unknown electroencephalographic characteristics, that has led to new insights and theories. NEW METHOD Taking into account that some network associations can(More)
PURPOSE Spike-and-wave discharges (SWDs) recorded in the cortical EEGs of WAG/Rij rats are the hallmark for absence epilepsy in this model. Although this type of epilepsy was long regarded as a form of primary generalized epilepsy, it is now recognized that there is an initiation zone - the perioral region of the somatosensory cortex. However, networks(More)
PURPOSE The organization of neural networks and the mechanisms, which generate the highly stereotypical for absence epilepsy spike-wave discharges (SWDs) is heavily debated. Here we describe such a model which can both reproduce the characteristics of SWDs and dynamics of coupling between brain regions, relying mainly on properties of hierarchically(More)
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