Marina V. Starostina

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OXYS rats with hereditary hyperproduction of active oxidative radicals and early disorders in the mitochondrial structure and functions are an interesting model for studies of age-specific features of synaptic plasticity. The formation of long-term posttetanic potentiation in the mossy fibers-CA3 pyramidal neuron system were studied in hippocampal slices(More)
The neuritogenic and neuroprotective activities of six starfish polar steroids, asterosaponin Р₁, (25S)-5α-cholestane-3β,4β,6α,7α,8,15α,16β,26-octaol, and (25S)-5α-cholestane-3β,6α,7α,8,15α,16β,26-heptaol (1-3) from the starfish Patiria pectinifera and distolasterosides D₁-D₃ (4-6) from the starfish Distolasterias nipon were analyzed using the mouse(More)
The effects of steroid compounds from Pacific Ocean starfishes were studied using cultured neuroblastoma C-1300 cells. Vital observations and examination of silver-impregnated preparations showed that the test substances in a concentration of 2-10 microM stimulate differentiation and improves survival of neuroblastoma cells under adverse conditions(More)
Effects of antiserum to S-100 protein (AS-100) in high (HC, corresponding to antiserum dilution 1:5 - 1:50) and low (LC, 1:10(12)) concentrations were studied in identified snail neurons and rat hippocampal slices. HC-AS-100 changed the frequency of action potential generation in spontaneously active neurons and blocked formation of long-term potentiation(More)
Immunofluorescence techniques were used to show that S100 is present on the surface of neuronal and glial membranes of Helix pomatia in vitro. By the method of rocket immunoelectrophoresis of aqueous , Trition, and n-pentanol extracts of snail nervous tissue, S100 was demonstrated to be mainly in the membrane fraction. Anti-S100 antiserum inhibited the(More)
Two new steroid glycosides: distolasteroside D6, (24S)-24-O-(beta-D-xylopyranosyl)-5alpha-cholestane-3beta,6alpha,8,15beta,16beta,24-hexaol, and distolasteroside D7. (22E,24R)-24-O-(beta-D-xylopyranosyl)-5alpha-cholest-22-ene-3beta,6alpha,8,15beta,24-pentaol were isolated along with the previously known distolasterosides D1, D2, and D3, echinasteroside C,(More)
1. Data on the presence of S-100 protein in synaptic endings are revised, and evidence is given in favor of its localization inside mouse brain cortex synaptosomes and on the surface of their external membrane. 2. For identification of the S-100-specific polypeptide, proteins of external synaptosomal membranes were iodinated with lactoperoxidase fixed on(More)
Fractions of neurospecific S-100 protein were purified from bovine brain and their physicochemical properties were studied. Conformational changes caused by the binding of calcium to S-100 protein fractions were detected by means of differential and fluorescence spectroscopy. Fractions demonstrating opposite shifts of their spectra also differ in the(More)
The content of calmodulin and S-100 protein in fractions of rat hippocampal slices was assayed by solid phase radioimmunology and radial immunodiffusion, respectively. One hour after tetanization (electrical stimulation of area dentata granular cells and recording from CA3 pyramids) an inverse translocation of these Ca++-binding proteins was observed: an(More)
Antibodies against S100 protein applied in high and ultra-high dilutions possess neuroprotective activity and maintain survival of neuroblastoma C-1300 cells under conditions of oxygen and glucose deprivation. The examined antibody preparations stimulated differentiation in neuroblastoma culture thereby demonstrating pronounced neurotrophic activity.