Marina Prewitz

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The spread of prostate cancer cells to the bone marrow microenvironment and castration resistant growth are key steps in disease progression and significant sources of morbidity. However, the biological significance of mesenchymal stem cells (MSCs) and bone marrow derived extracellular matrix (BM-ECM) in this process is not fully understood. We therefore(More)
Mouse embryonic stem cells (mESCs) undergo self-renewal in the presence of the cytokine, leukaemia inhibitory factor (LIF). Following LIF withdrawal, mESCs differentiate, and this is accompanied by an increase in cell-substratum adhesion and cell spreading. The purpose of this study was to investigate the relationship between cell spreading and mESC(More)
Polymeric biomaterials can be instrumental for expanding and differentiating stem and progenitor cells in culture. Key to success of these approaches is the defined modulation of biomolecular and physical signals governing cellular microenvironments. Current concepts for effective stem cell culture carriers rely on cell-secreted decellularized matrices,(More)
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