Marina Porcelli

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The present study was designed to evaluate the effects of diet lifestyle on extending lifespan and reducing liver cancer risk. Young overweight men (n = 20), without metabolic syndrome, were placed in a 3-week residential program on a low-fat diet and moderate aerobic exercise. In each subject, pre- and postintervention fasting blood were collected for(More)
Oxidative stress plays a major role in ethanol-induced liver damage, and agents with antioxidant properties are promising as therapeutic opportunities in alcoholic liver disease. In the present work, we investigated the effect of S-adenosylmethionine (AdoMet), Tyrosol (Tyr), and their combination on HepG2 cells exposed to ethanol exploring the potential(More)
Posttranslational hypusine modification of lysine 50 of the eukaryotic initiation factor 5A (eIF-5A) is associated with the function of this factor in cell proliferation and differentiation and is involved in tumor formation, progression and maintenance (for a review see ref. 1). In a Molecular Therapy Issue, Francis et al. report that knock down of(More)
Nucleoside hydrolases (NHs) are a class of metalloproteins that catalyze the irreversible hydrolysis of the N-glycosidic bond of β-ribonucleosides forming ribose and purine or pyrimidine base. In the hyperthermophilic archaeon Sulfolobus solfataricus, two NHs have been purified and extensively characterized. Although these enzymes show different substrate(More)
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