Marina Penteado

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The hypotheses that iron-deficient hosts are less susceptible to severe malaria and that iron supplementation aggravates infection have been supported by some clinical and experimental evidence. In the present study, the course of Plasmodium berghei infection was monitored in an experimental model of dietary iron deficiency and iron supplementation.(More)
The inhibitory effects of beta-carotene or vitamin A on preneoplastic lesions induced in rats were compared, when specifically administered during early promotion of hepatocarcinogenesis. Initiation was performed by diethylnitrosamine. During the selection/promotion period 2-acetylaminofluorene was administered, and a partial hepatectomy was performed.(More)
Clinical and experimental evidence suggests that iron-deficient hosts are less susceptible to severe malaria and that iron supplementation aggravates infection. In the present study, 60 weanling Wistar rats were fed standard diets with different iron concentrations: 21 mg/kg (group 1), 45 mg/kg (group 2) and 113 mg/kg (group 3). Ferrous sulfate (FeSO4 x(More)
The inhibitory effects of beta-carotene (BC) on preneoplastic lesions induced in male Wistar rats by the resistant hepatocyte model was investigated. Rats were divided into six groups. Initiation was performed in all animals by a single injection of diethylnitrosamine. During the selection/promotion period five doses of 2-acetylaminofluorene were(More)
The effects of beta-carotene (beta C) or vitamin A (VA) administration for 8 consecutive weeks were compared in male Wistar rats submitted to the resistant hepatocyte model (RH model) of hepatocarcinogenesis. Animals treated with corn oil (CO), instead of carotenoid or retinoid, served as controls. At the end of the study, beta C treatment resulted in a(More)
This review was elaborated in order to contribute to the planning of strategies for controlling iron deficiency anemia in developing countries. The need for intervention should be determined by the degree of iron deficiency in the individual group and knowledge of its effects on quality of life, morbidity, and mortality. The most frequent approach is to(More)
The morphology of livers of Wistar rats treated with beta-carotene (BC), vitamin A (VA, retinol acetate) or corn oil (CO, controls) and submitted to the resistant hepatocyte model of carcinogenesis was studied. Preneoplastic lesions (PNL) were smaller and less numerous in the BC group. The latter group also presented fewer placental(More)
*Correspondence: P. C. Ferrari. Departamento de Ciências Farmacêuticas. Universidade Estadual de Ponta Grossa. Avenida General Carlos Cavalcanti, 4748, 84030-900 – Uvaranas Ponta Grossa, PR, Brazil. Tel. 55-42-3220 3782. E-mail: priscileila@hotmail.com / pcferrari@uepg.br Floating ability and drug release evaluation of gastroretentive microparticles system(More)
Carotenoids pigments in crude and refined oils from Brazilian palm were analyzed. Beta-carotene was the principal fraction detected in all samples, varying from 142.6 micrograms/g to 314.25 micrograms/g in crude palm oils; from 132.55 micrograms/g to 612.16 micrograms/g in Brazilian palm kernels; and from 139.4 to 168.90 micrograms/g in refined palm oils.(More)