Marina P Samoilovich

Learn More
Early embryos of many organisms develop outside the mother and are immediately confronted with myriads of potential colonizers. How these naive developmental stages control and shape the bacterial colonization is largely unknown. Here we show that early embryonic stages of the basal metazoan Hydra are able to control bacterial colonization by using maternal(More)
Based on our own results and literature data, a comparative analysis is performed of particularities of mechanisms of defense from pathogens in representatives of Bivalvia and Gastropoda. The agglutinating and opsonizing activities of plasma from molluscs of phylogenetically distant species were revealed to differ significantly. These differences may be(More)
The work deals with the description of a novel antigen marker of differentiated foot cells of polyps of the Hydra genus. The antigen called 3G11 has been revealed by a monoclonal antibody of the same name in granules of the ectodermal secretory cells of the basal disc. The appearance of the antigen in the developing foot tissue during budding and(More)
Molecules of secretory immunoglobulins (Ig) of classes A and M (sIgA and sIgM) play the main role in protection of mucosae from pathogenic factors. The apparatus of synthesis of these molecules represent the most powerful part of the immune system. One of the key elements of the sIgA and sIgM is J-chain. It represents an acid polypeptide of molecular mass(More)
Adaptive immune systems are present only in vertebrates. How do all the remaining animals withstand continuous attacks of permanently evolving pathogens? Even in the absence of adaptive immunity, every organism must be able to unambiguously distinguish "self" cells from any imaginable "nonself." Here, we analyzed the function of highly polymorphic gene(More)
Endoglin (CD105), a component of TGF-β, BMP-9, BMP-10 binding receptor complexes, is the marker of endothelial and mesenchymal stem cells. Its expression is significantly increased in the blood vessel endothelium of ischemic tissues and growing tumors. Measurement of the endoglin soluble form in serum and urine is used in diagnostics of cancer and pregnancy(More)
Mesenchymal stromal cells were isolated from the adipose tissue obtained during surgery for breast cancer and cultured under conditions of normal or low oxygen concentrations. In patients that had received a course of radiation and polychemotherapy prior to surgery, the proliferative potential of mesenchymal stromal cells was irreversibly disturbed. In(More)
The goal of the study was to obtain a panel of monoclonal antibodies (MAb) against antigens of freshwater polyps of the genus Hydra. Hybrid mice F1(Balb/c × SJL/J) were immunized with cell membrane fraction of H. vulgaris and three months later their splenocytes were fused with cultured mouse myeloma cells 653A. Testing of culture fluids in ELISA with(More)
Endotoxin (LPS) and radio-detoxified endotoxin (RD-LPS: 150 kGy 60Co-gamma irradiated) preparations were compared in mice (C57Bl X CBA: F1/Rapo) for capacity to enhance the immune response against sheep red blood cells and to induce the production of antibody against autologous (bromelain-treated) erythrocytes. As RD-LPS retains its capacity to stimulate(More)