Marina Nebieridze

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We studied the effects of morphine in high doses on astrocytes in the nucleus accumbens, lateral septum, and caudate nucleus of rat brain. Activation of astrocytes in the nucleus accumbens and lateral septal nucleus was manifested in hyperplasia and elongation of astrocyte processes. In the caudate nucleus, the total length of astrocyte processes and(More)
Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus. Several lines of investigations have shown that in some brain areas, particularly the midbrain(More)
The purpose of the study was to estimate efficiency of atorvastatin in complex treatment with antiarhythmic drugs on the background of ischemic heart disease in patients with paroxysmal atrial fibrillation (AF). The investigation was conducted on 65 patients (37-72 years old) during 2 years. Two groups were composed. The first group included 28 patients who(More)
One of the main methods the treatment of patients with supraventricular paroxysmal tachycardia remains drug therapy, which involves the prevention attacks of cardiac arrhythmias. Drugs of choice for termination and prevention of paroxysmal supraventricular tachycardia in the absence of pronounced signs structural myocardial damage is an antiarrhythmic with(More)
The aim of the study was to estimate efficiency and safety of treatment by non-direct anticoagulant--warfarex in the patients with persistent and paroxysmal forms of AF for the prevention of thromboembolic complications. 55 patients between 37 and 75 years old with atrial fibrillation (AF) were investigated. Follow-up was 2 years. Primary diseases were post(More)
These clinical trials show the efficiency of therapy with angiotensin-converting enzyme (ACE) inhibitors in essential hypertension (EH), chronic heart failure and coronary heart disease (CHD). The SMILE studies have indicated positive results of the early administration (<24 hours) of zofenopril in patients with acute myocardial infarction (AMI). These(More)
Several lines of investigations have shown that in some brain areas, in particular, in the midbrain periaqueductal gray matter, rostral ventromedial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of nonsteroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of(More)
Non-invasion model for photochemically induced brain infarction was used to study the effect of a the new anti-ischemic drug LB ("Plaferon") in albino rats. Intensity of a local blood flow was measured so as oxygen tension in brain cortex. Square and volume of the disturbed nervous tissue region, capillary length and density of distribution of different(More)
The aim of this study was revealing the temperature changes in rats’ brain tissue caused by whole body hyperthermia. The analysis of received results allows to conclude that the brain has a highly secured system of temperature autoregulation against the exogenous temperature changes.The upper limit of this autoregulation (for rats, at least) is in the range(More)