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In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers.(More)
HTLV-1 Associated Myelopathy/Tropical spastic parapar-esis (HAM/TSP) is the classical neurological syndrome associated with this retrovirus, although other neurological complications are described. We collected data in the neu-rological and epidemiological databases related of the GIPH cohort, from 1997 and 2012, as well as in the records of the(More)
BACKGROUND The RHD gene is highly polymorphic, which results in a large number of RhD variant phenotypes. Discrepancies in RhD typing are still a problem in blood banks and increase the risk of alloimmunization. In this study, the RhD typing strategy at a blood bank in Brazil was evaluated. METHODS One-hundred and fifty-two samples typed as RhD negative(More)
HTLV-1-associated myelopathy (HAM) is a classic neuro-logical disease, but cognitive impairment and altered signal intensity on MRI scans of the brain are described in the literature and suggest a more extensive neurological damage. This is a cross-sectional study, conducted between March 17 th and September 28 th , 2012 in the GIPH cohort, Brazil. HAM was(More)
Since 1997, the Interdisciplinary Research Group on HTLV-1/2 (GIPH) has been following individuals infected with HTLV in Minas Gerais, Brazil, in an open prospective cohort study. The HAM diagnosis is based on clinical parameters, with support of complementary exams to exclude other possible causes of myelopathy. The objective of this study was to evaluate(More)
OBJECTIVE To implement genotyping for S, s and U antigens of the MNS blood group system at the Fundação Hemominas and to evaluate the occurrence of GYPB gene polymorphisms associated with the U- and U+var phenotypes and deletion of the GYPB gene for the first time in an admixed population of Minas Gerais, Brazil. The S, s and U antigens can cause(More)
HTLV-1 proviral load (pvl) is an important risk marker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its value as prognostic marker is not well defined. Long-term prospective cohort studies are necessary to clarify this question. Here, we analyzed HTLV-1 pvl in the peripheral blood of 82 asymptomatic carriers (AC; 351(More)
DARC polymorphism that abrogates erythrocyte Duffy antigen expression influences MCP-1 plasma level in HTLV-1 infected individuals but are not associated with HAM/TSP Genetic host factors influence the outcome of HTLV-1 infection. Chemokines are important in the immune response against virus, and play a role in HAM/TSP pathogenesis. Duffy antigen receptor(More)