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In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers.(More)
OBJECTIVE To evaluate the geographic distribution of human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in the State of Minas Gerais, Brazil, in puerperal women whose newborns were tested for HTLV-1/2 during neonatal screening, and to overlap seropositivity with social and economic status determinants. METHODS During September-November 2007, the(More)
HTLV-1 Associated Myelopathy/Tropical spastic parapar-esis (HAM/TSP) is the classical neurological syndrome associated with this retrovirus, although other neurological complications are described. We collected data in the neu-rological and epidemiological databases related of the GIPH cohort, from 1997 and 2012, as well as in the records of the(More)
Although human T-cell lymphotropic viruses (HTLV-1/2) were described over 30 years ago, they are relatively unknown to the public and even to healthcare personnel. Although HTLV-1 is associated with severe illnesses, these occur in only approximately 10% of infected individuals, which may explain the lack of public knowledge about them. However, cohort(More)
OBJECTIVE To implement genotyping for S, s and U antigens of the MNS blood group system at the Fundação Hemominas and to evaluate the occurrence of GYPB gene polymorphisms associated with the U- and U+var phenotypes and deletion of the GYPB gene for the first time in an admixed population of Minas Gerais, Brazil. The S, s and U antigens can cause(More)
BACKGROUND The RHD gene is highly polymorphic, which results in a large number of RhD variant phenotypes. Discrepancies in RhD typing are still a problem in blood banks and increase the risk of alloimmunization. In this study, the RhD typing strategy at a blood bank in Brazil was evaluated. METHODS One-hundred and fifty-two samples typed as RhD negative(More)
HTLV-1-associated myelopathy (HAM) is a classic neuro-logical disease, but cognitive impairment and altered signal intensity on MRI scans of the brain are described in the literature and suggest a more extensive neurological damage. This is a cross-sectional study, conducted between March 17 th and September 28 th , 2012 in the GIPH cohort, Brazil. HAM was(More)
Since 1997, the Interdisciplinary Research Group on HTLV-1/2 (GIPH) has been following individuals infected with HTLV in Minas Gerais, Brazil, in an open prospective cohort study. The HAM diagnosis is based on clinical parameters, with support of complementary exams to exclude other possible causes of myelopathy. The objective of this study was to evaluate(More)