Marina Golombek

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The cyclic purine nucleotides cAMP and cGMP are well-characterized second messengers and activators of PKA and PKG, respectively. In contrast, the functions of the cyclic pyrimidine nucleotides cCMP and cUMP are poorly understood. cCMP induces relaxation of smooth muscle via PKGI, and phosphodiesterases differentially hydrolyze cNMPs. Here, we report that(More)
cCMP is a cyclic pyrimidine nucleotide which binds to and activates cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG). In S49 lymphoma cells, cAMP induces apoptosis via PKA. In our present study, we examined the effect of cCMP on apoptosis in S49 mouse lymphoma cells and in PKA-deficient S49kin(-)cells. These two cell lines also(More)
There is increasing evidence for a role of cytidine 3′,5′-cyclic monophosphate (cCMP) as second messenger. In a recent study, we showed that cCMP activates both purified guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase Iα (PKG Iα) and adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent protein kinase (PKA) isoenzymes with the(More)
Introduction cAMP and cGMP are second messengers that play important roles in intracellular signal transduction of various external stimuli. Major functions of both are the activation of cAMP-dependent protein kinase A (PKA) and cGMP-dependent protein kinase G (PKG), respectively. PKA and PKG are members of the serine-threonine protein kinase superfamily(More)
Background cGMP-dependent protein kinase (PKG) is a serine/ threonine kinase which is potently activated by cGMP [1]. PKG is encoded by two genes, forming two different proteins, PKGI and PKGII. The two isoforms of PKGI, PKGIa and PKGIb, differ in the N-terminal amino acid sequences. PKGI isozymes are homodimers with two identical subunits possessing a(More)
The influence of benzydamine (Tantum) on the prostaglandin metabolism of rat peritoneal macrophages was studied. Contrary to conventional non-steroidal antiinflammatory drugs, e.g. piroxicam and acetylsalicylic acid, benzydamine did not inhibit PGE1/2 synthesis, but was rather stimulatory at 10(-4) mol/l. The increase of PGE1/2 synthesis might be explained(More)
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