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BACKGROUND Patients with homozygous familial hypercholesterolaemia respond inadequately to existing drugs. We aimed to assess the efficacy and safety of the microsomal triglyceride transfer proteinExpand
  • Margarita de la Llera-Moya, Denise Drazul-Schrader, Bela F Asztalos, Marina Cuchel, Daniel J. Rader, George H. Rothblat
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 2010 (First Publication: 1 April 2010)
  • Objective—We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C)Expand
  • Gérard Siest, Philippe Bertrand, +24 authors the ApoEurope group13
  • Medicine
  • Clinical chemistry and laboratory medicine
  • 2000 (First Publication: 21 January 2000)
  • Abstract As part of the ApoEurope Project, apolipoprotein E (apo E) common polymorphism and serum concentration were determined in 489 Alzheimer's disease patients and 429 controls. Patients andExpand
  • Jahangir Iqbal, Meghan T. Walsh, +7 authors Mohammed Hussain
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2015 (First Publication: 8 September 2015)
  • Background: It is unknown how sphingolipids arrive at plasma. Results: Plasma ceramide and sphingomyelin are low in microsomal triglyceride transfer protein (MTP)-deficient humans and mice. MTP doesExpand
  • Sony Tuteja, Danielle Duffy, +4 authors Marina Cuchel
  • Medicine
  • Pharmacotherapy
  • 2014 (First Publication: 1 March 2014)
  • STUDY OBJECTIVE To characterize the effects of two doses (10 and 60 mg) of lomitapide—a microsomal triglyceride transfer protein inhibitor approved as adjunct treatment to lower low-densityExpand
  • Marina Cuchel, Ursula S Schwab, +7 authors Alice H Lichtenstein
  • Chemistry, Medicine
  • Metabolism: clinical and experimental
  • 1996 (First Publication: 1 February 1996)
  • The effects of replacing corn oil with corn oil margarine in stick form on endogenous cholesterol synthesis and susceptibility of low-density lipoprotein (LDL) to oxidation were assessed in 14Expand