Marilyn McHugh

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BACKGROUND Recent studies have suggested that supraspinal structures are involved in barbiturate-induced enhancement of nociceptive processing. The goal of the study was to determine whether cortical and subcortical regions involved in nociception were relatively activated or depressed by noxious stimulation during infusion of small doses of thiopental. (More)
It was shown previously that focal cortical freezing lesions in rats cause widespread decrease in local cerebral glucose utilization (LCGU) in cortical areas of the lesioned hemisphere. This was interpreted as reflecting a depression of cortical activity. It was then demonstrated that cortical serotonin (5-HT) metabolism was increased throughout the(More)
i ii Acknowledgements The research team would like to thank the following people for their valuable assistance and support throughout the project: The project was managed by Phil Smith and Sharon Storey from the Out-of-Home Care Directorate of DoCS and Marilyn Chilvers from Statistical Services Branch of DoCS who provided support, information and advice.(More)
Freezing lesions have been shown to cause a depression in glucose use, particularly in cortical areas of the brain ipsilateral to the lesion, and this effect was interpreted to be caused by a depressed functional activity in these regions. The metabolic status of the affected areas has not been previously examined and could be a factor in the observed(More)
Acknowledgements We would like to thank all the participants for the time they committed to the project including the families, managers and field workers. We would also like to acknowledge the contribution of the Office of Childcare for their ongoing support and advice, and Marilyn Chilvers, Director of Statistical Services and her unit for collecting the(More)
Focal freezing lesions in rats cause a widespread decrease of cortical glucose utilization in the lesioned hemisphere, probably as a reflection of depressed cortical activity. The noradrenergic neurotransmitter system was implicated in these alterations when it was demonstrated that prazosin, a specific norepinephrine (NE) antagonist at alpha 1-adrenergic(More)