Marilyn Algire

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BACKGROUND & AIMS Neonatal intestinal obstruction (meconium ileus [MI]) occurs in 15% of patients with cystic fibrosis (CF). Our aim was to determine the relative contribution of genetic and nongenetic modifiers to the development of this major complication of CF. METHODS A total of 65 monozygous twin pairs, 23 dizygous twin/triplet sets, and 349 sets of(More)
RATIONALE Obstructive lung disease, the major cause of mortality in cystic fibrosis (CF), is poorly correlated with mutations in the disease-causing gene, indicating that other factors determine severity of lung disease. OBJECTIVES To quantify the contribution of modifier genes to variation in CF lung disease severity. METHODS Pulmonary function data(More)
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