Marileen P. Portegies

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BACKGROUND Cerebral microbleeds are highly prevalent in people with clinically manifest cerebrovascular disease and have been shown to increase the risk of stroke recurrence. Microbleeds are also frequently found in healthy elderly, a population in which the clinical implication of microbleeds is unknown. METHODS AND RESULTS In the population-based(More)
BACKGROUND An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. METHODS Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI)(More)
IMPORTANCE Intracranial atherosclerosis represents a relatively unexplored, but potentially important, cause of stroke in a white population. OBJECTIVE To investigate the relationship between intracranial carotid artery calcification (ICAC) as a marker of intracranial atherosclerosis and the risk of stroke in whites. DESIGN, SETTING, AND PARTICIPANTS A(More)
Automated brain segmentation methods with a good precision and accuracy are required to detect subtle changes in brain volumes over time in clinical applications. However, the ability of established methods such as SIENA, US and kNN to estimate brain volume change have not been compared on the same data, nor been evaluated with ground-truth manual(More)
OBJECTIVE To evaluate differences in first manifestations of cardiovascular disease between men and women in a competing risks framework. DESIGN Prospective population based cohort study. SETTING People living in the community in Rotterdam, the Netherlands. PARTICIPANTS 8419 participants (60.9% women) aged ≥ 55 and free from cardiovascular disease at(More)
OBJECTIVE To investigate the association between cardiac function and the risk of stroke and dementia in elderly free of clinical cardiac disease. Additionally, we investigated the relation between cardiac function and MRI markers of subclinical cerebrovascular disease. METHODS This study was conducted within the population-based Rotterdam Study. A total(More)
AIMS It has been suggested that in patients with type 2 diabetes mellitus (T2DM), brain atrophy is most pronounced in the hippocampus, but this has not been investigated systematically. The present pooled analysis of three studies examined if hippocampal atrophy is more prominent than global brain atrophy in patients with T2DM relative to controls. (More)
BACKGROUND Cardiovascular factors and low education are important risk factors of dementia. We provide contemporary estimates of the proportion of dementia cases that could be prevented if modifiable risk factors were eliminated, i.e., population attributable risk (PAR). Furthermore, we studied whether the PAR has changed across the last two decades. (More)
BACKGROUND Higher education is associated with a lower risk of dementia, possibly because of a higher tolerance to subclinical neurodegenerative pathology. Whether higher education also protects against dementia after clinical stroke or transient ischemic attack (TIA) remains unknown. METHODS Within the population-based Rotterdam Study, 12,561(More)
BACKGROUND AND PURPOSE Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is a predictor of heart disease. It has also been related to stroke, but its association with transient ischaemic attacks (TIAs) is unclear. Moreover, it is unknown how clinical heart disease influences this relation. Within the prospective population-based Rotterdam Study, the(More)
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