Mariko Yamamoto

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Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive motoneuron loss. Redistribution of transactive response deoxyribonucleic acid-binding protein 43 from the nucleus to the cytoplasm and the presence of cystatin C-positive Bunina bodies are considered pathological hallmarks of amyotrophic lateral sclerosis, but(More)
The brain capillary endothelial cell (BCEC) is a major functional component of the blood-brain barrier and is an underlying factor in the pathophysiology of various diseases, including brain ischemia, multiple sclerosis, and neurodegenerative disorders. We examined gene silencing in BCECs by using endogenous lipoprotein to introduce short-interfering RNA(More)
Gene therapy for neuropathic pain requires efficient gene delivery to both central and peripheral nervous systems. We previously showed that an adenoassociated virus serotype 9 (AAV9) vector expressing short-hairpin RNA (shRNA) could suppress target molecule expression in the dorsal root ganglia (DRG) and spinal cord upon intrathecal injection. To evaluate(More)
C ulture appears to affect body image in general and body esteem in particular, yet do cultural differences in these constructs concern with factorial structure or merely the magnitude of their manifestation? This study examined what body parts and functions the body esteem of young Japanese adults consists of, and assessed its relation with several other(More)
Time required for bathing-related care for nursing home residents with various stages of severe dementia were observed. Time required for each resident, including guiding to the bathroom, undressing, and dressing were plotted in graphs in order to make comparisons. The situations and conversations observed for the instances when additional time was needed(More)
The study examined the impact of dementia severity on repeat fallers among the institutionalized elderly. A secondary analysis of a dataset containing information on 466 residents (86 of whom were fallers) of nine care facilities around Tokyo was carried out. Descriptive statistics were used to determine the baseline characteristics. Then, logistic(More)
Perceptions of America as a powerful but malevolent nation decrease its security. On the basis of measures derived from the stereotype content model (SCM) and image theory (IT), 5,000 college students in 11 nations indicated their perceptions of the personality traits of, intentions of, and emotional reactions to the United States as well as their reactions(More)
Gene therapy for neurological diseases requires efficient gene delivery to target tissues in the central and peripheral nervous systems. Although adeno-associated virus is one of the most promising vectors for clinical use against neurological diseases, it is difficult to get it across the blood-brain barrier. A clinically practical approach to using a(More)
Dogs are filling a growing number of roles supporting people with various disabilities, leading to a chaotic situation in the U.S. Although the federal laws allow public access with working dogs only for people with disabilities, no governmental enforcement or management system for such dogs exists. Furthermore, there is no substantive way to confirm(More)
BACKGROUND A noninvasive technique to monitor thermal lesion formation is necessary to ensure the accuracy and safety of high-intensity focused ultrasound (HIFU) treatment. The purpose of this study is to ultrasonically detect the tissue change due to thermal coagulation in the HIFU treatment enhanced by cavitation microbubbles. METHODS An ultrasound(More)