Mariko Fujimoto

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Dendritic cells (DCs), which differentiate in vitro from peripheral blood monocytes (PBMOs) or bone marrow precursors, are a promising candidate for immunotherapy against cancer. The dog, which suffers common types of cancers along with humans, make an ideal large animal model for cancer studies. Monocyte-derived DCs in the dog have not been well(More)
Poly(ethylene glycol) (PEG) hydrogels cross-linked by a hydrolyzable polyrotaxane containing hydroxyapatite particles (PRX-HAp) were developed as scaffolds for bone regeneration. Five scaffolds with various composition of the polyrotaxane, PEG and HAp particles were prepared to examine cell adhesion in vitro using rat primary cultured osteoblast. Cells were(More)
A flu-like disease spread among chimpanzees (Pan troglodytes schweinfurthii) of the M group at Mahale Mountains National Park, Tanzania, from June to July 2006. This epizootic or epidemic killed up to 12 chimpanzees. The obvious evidence of their deaths came from finding the bodies of three infants who had previously shown some symptoms of the disease. At(More)
To construct a vector for caspase-1 independent expression of canine IL-18, the signal sequence of canine IL-12p40 was fused to the sequence of mature IL-18 on the NdeI restriction site which is located at the 3' end of the signal sequence. The resulting vector expressed coding protein from transfected mammalian cells. The expressed protein was shown to(More)
IL-12 is a cytokine produced by dendritic cells (DC) and activates cytotoxic T cells and NK cells against tumors. We investigated the effect of IL-12 on DC. When peripheral blood monocytes were incubated with canine granulocyte-macrophage (GM)-CSF and IL-4, expression of MHC class II, CD1a, CD80 and CD86 was significantly elevated, but the cell morphology(More)
This is the first report documenting the responses of wild chimpanzees (Pan troglodytes schweinfurthii) to seismic activities. During our long-term fieldwork in Mahale Mountains National Park, Tanzania, a high-intensity earthquake with a Richter magnitude of 6.8 occurred at 15:19 hours local time on 5 December 2005. During the main tremor, the chimpanzees(More)
We have analyzed the ranging patterns of the Mimikire group (M group) of chimpanzees in the Mahale Mountains National Park, Tanzania. During 16 years, the chimpanzees moved over a total area of 25.2 or 27.4 km2, as estimated by the grid-cell or minimum convex polygon (MCP) methods, respectively. Annually, the M group used an average of 18.4 km2, or(More)
meaning that human observers were also there on a regular basis. Second, because Psydrax trees are relatively short with sparse canopies, it was easy for the observer to notice the dead body. We may not have been able to notice the remains if a higher and denser-canopied tree were involved or in a place less frequented by the chimpanzees. In such cases, we(More)
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