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BACKGROUND/PURPOSE The penetration depth of light in diffuse reflectance near-infrared spectroscopy for measuring water content in skin is assessed both from theoretical and experimental points of view. METHODS The Monte Carlo simulation was implemented to investigate the dependencies of the light penetration depth on a source-detector distance. To(More)
The water content of human nail plates was determined using a portable near-infrared (NIR) spectrometer with an InGaAs photodiode array detector. NIR diffuse reflectance (DR) spectra were collected from 108 cut nail plates with different relative humidity and in vivo from fingernails. Partial least-squares (PLS) regression was applied to the NIR spectra in(More)
BACKGROUND/AIMS Changes in the skin conditions after exposure to low humidity have been generally experienced in everyday life, but there have been few reports to approach it-especially in healthy skin. We have examined the effect of low humidity on healthy human skin by using noninvasive measurement devices. METHODS Skin conditions on the ventral forearm(More)
Stratum corneum thickness was estimated from water concentration profiles of the skin measured by a confocal Raman spectrometer. Stratum corneum apparent thickness (SCAT) was defined as the depth where the water content reached an almost constant value. Site variations were determined using 15 healthy Japanese subjects (6 males, 9 females), and age(More)
BACKGROUND Dermatologists and cosmetic scientists are becoming increasingly interested in stratum corneum (SC) hydration because the SC plays an important role in keeping the skin surface soft and smooth. However, conventional in vivo noninvasive methods do not provide direct information about the depth profiles of water content or SC components that hold(More)
BACKGROUND/AIMS Recently, there has been increasing awareness regardless keeping nails in good condition. Maintenance of an optimum water level in the nail plate is very important since water content affects the nail condition. However, a simple method for in vivo measurement of water in the nail plate quantitatively has not been reported. In this study, we(More)
  • Mariko Egawa
  • 2009
BACKGROUND/PURPOSE As near-infrared spectroscopy is a powerful non-invasive technique, information about several functional groups such as OH, NH, and CH can be monitored simultaneously. This study aimed to coincidentally measure urea and water contents in the human stratum corneum after the treatment of urea-containing cream, in vivo, by a Fourier(More)
BACKGROUND/PURPOSE Water in the stratum corneum (SC) plays an important role in keeping the skin surface soft and smooth. Information regarding the depth profile of the molecular composition of the skin, such as water and free amino acids, can be obtained non-invasively using the recently developed confocal Raman spectrometer. In this study, we investigated(More)
BACKGROUND/PURPOSE We investigate the measurement sensitivity for the water content distribution in Near-infrared (NIR) imaging ranging up to 2 μm. METHODS To evaluate the sensitivity, our attention is focused to the light penetration depth in the skin tissue because the thickness of a layer where the water content can be varied is very thin and deep(More)