Marika Sculco

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Diamond Blackfan anaemia (DBA) is a congenital bone marrow failure syndrome characterised by selective red cell hypoplasia. DBA is most often due to heterozygous mutations in ribosomal protein (RP) genes that lead to defects in ribosome biogenesis and function and result in ribosomal stress and p53 activation. The molecular mechanisms underlying this(More)
BACKGROUND CONTEXT Aerobic exercise (AE) has been prescribed to improve fitness and well-being in apparently healthy individuals and cardiac, orthopedic, and other patient populations. AE has not previously been studied as a sole treatment for low back pain patients (LBPP). PURPOSE This study evaluated the effects of low to moderate aerobic exercise as an(More)
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos exposure. An inherited predisposition has been suggested to explain multiple cases in the same family and the observation that not all individuals highly exposed to asbestos develop the tumor. Germline mutations in BAP1 are responsible for a rare cancer predisposition(More)
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