Marika Poppe

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Cell lines producing biopharmaceuticals with high yield and high quality in a regulatory compliant environment are a prerequisite for cost effective bioproductions. The development of these production cell lines often includes screening strategies combined with gene amplification and limited dilution experiments, a time consuming process. Especially gene(More)
The random nature of transgene integration harbours various pitfalls for development of production cell lines including clonal variation in expression level and growth characteristics. The CEMAX system is an expression system for targeted integration of expression cassettes via DNA double-strand break induced homologous recombination. Stable high producers(More)
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