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UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
Uncoordinated movement in Rab2 mutants is caused by impaired retention of cargo on dense core vesicles, not by defective synaptic vesicle release. (Also see the companion article by Edwards et al. inExpand
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans
TLDR
It is shown here that the formation of release-competent DCVs requires a reciprocal exclusion cascade coupling RAB-5 and Rab-10, in which each of the two Rabs recruits the other’s GAP molecule. Expand
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling.
TLDR
By showing that the genes fat-3 and synaptojanin act in the same endocytic pathway at synapses, this work suggests that LC-PUFAs are required for efficient synaptic vesicle recycling, probably by modulating synapt Mojanin localization atsynapses. Expand
Succinate Dehydrogenase Upregulation Destabilize Complex I and Limits the Lifespan of gas-1 Mutant
TLDR
It is demonstrated that increase in complex I stability, improves mitochondrial function and decreases mitochondrial stress, putting Caenorhabditis elegans mutants inside a “window” of mitochondrial dysfunction that allows lifespan prolongation. Expand
The role of UNC-108/RAB-2 in neuronal dense core vesicle maturation in C. elegans
TLDR
The functional defects causing reduced locomotion in unc-108/rab-2 mutant animals are analyzed and it is concluded that RAB-2 and its effector RIC-19 are necessary for DCV maturation and normal neurotransmission at the neuromuscular junction. Expand