Marienela Buendia

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BACKGROUND This study aimed to compare the therapeutic efficacy of two treatments for childhood acute lymphoblastic leukemia (ALL), and to evaluate the feasibility of intensive chemotherapy in a developing country. METHODS The study was conducted at the National Cancer Institute in Bogota, Colombia. Untreated ALL patients under 16 years of age were(More)
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling has been associated with increased proliferative capabilities, invasiveness, and chemoresistance in several types of cancer. However, the relevance of this pathway in MB remains(More)
We read with great interest the recent article by Ni et al.1 on the role of the tyrosine receptor kinase B (TrkB) as a drug target for the treatment of astrocytomas. Among central nervous system tumors, astrocytomas are the most frequent type of glioma, and grade IV astrocytoma (also called glioblastoma) is the most aggressive type of primary brain cancer.(More)
Neuroblastoma (NB) is the most common extracranial solid childhood tumor accounting for around 15% of pediatric cancer deaths and most probably originates from a failure in the development of embryonic neural crest cells. Retinoids can inhibit the proliferation and stimulate differentiation of NB cells. In addition, epigenetic events involving changes in(More)
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