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Understanding the evolution of neonatal hypoxic/ischemic is essential for novel neuroprotective approaches. We describe the neuropathology and glial/inflammatory response, from 3 hours to 100 days, after carotid occlusion and hypoxia (8% O(2), 55 minutes) to the C57/BL6 P7 mouse. Massive tissue injury and atrophy in the ipsilateral (IL) hippocampus, corpus(More)
We studied the effects on the auditory brainstem response (ABR) of applying a computerized calibration procedure for click stimuli that corrects for individual transducer characteristics and ear canal acoustics. The "calibrated" signal at the eardrum possesses a nearly flat spectrum from 500 to 10,000 Hz. ABRs were recorded from normal-hearing subjects(More)
During postnatal development, microglia, the resident innate immune cells of the central nervous system are constantly monitoring the brain parenchyma, cleaning the cell debris, the synaptic contacts overproduced and also maintaining the brain homeostasis. In this context, the postnatal microglia need some control over the innate immune response. One such(More)
Children (aged 7-10 yrs) who were referred because of learning disabilities and found to have abnormal SSW scores were divided into Experimental and Control Groups. All had essentially normal pure-tone ac HTLs, tympanograms, and W-22 word discrimination scores. Pre-therapy baselines were also obtained on a speech-to-noise (S-in-N) task, a test of phonemic(More)
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