Marieke den Brinker

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OBJECTIVE To investigate the risk of hepatotoxicity after initiation of protease inhibitor-containing highly active antiretroviral therapy (HAART) for HIV-1 infected patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) co-infection. DESIGN Retrospective study with 394 HIV-1-infected patients initiating HAART at a single university(More)
CONTEXT Adequate adrenal function is pivotal to survive meningococcal sepsis. OBJECTIVES The objective of the study was to evaluate adrenocortical function in meningococcal disease. DESIGN This was an observational cohort study. SETTING The study was conducted at a university-affiliated pediatric intensive care unit. PATIENTS Sixty children with(More)
OBJECTIVE To evaluate the role of cholesterol and lipoproteins in children with severe meningococcal sepsis. DESIGN Retrospective observational study. SETTING A university-affiliated pediatric intensive care unit. PATIENTS Fifty-seven patients admitted to the pediatric intensive care unit with meningococcal sepsis or septic shock. INTERVENTIONS(More)
INTRODUCTION The objective of this study was to investigate the occurrence of hyperglycemia and insulin response in critically ill children with meningococcal disease in the intensive care unit of an academic children's hospital. METHODS Seventy-eight children with meningococcal disease were included. The group was classified into shock non-survivors,(More)
OBJECTIVE To investigate the effect of one single bolus of etomidate used for intubation on adrenal function in children with meningococcal sepsis. DESIGN Retrospective study conducted between 1997 and 2004. SETTING University-affiliated paediatric intensive care unit (PICU). PATIENTS AND PARTICIPANTS Sixty children admitted to the PICU with(More)
This study aimed to evaluate the time course of perioperative blood glucose levels of children undergoing cardiac surgery for congenital heart disease in relation to endogenous stress hormones, inflammatory mediators, and exogenous factors such as caloric intake and glucocorticoid use. The study prospectively included 49 children undergoing cardiac surgery.(More)
CONTEXT AND OBJECTIVES The objective of this study was to elucidate the influence of disease severity, deiodination, sulfation, thyroid hormone binding, and dopamine use on thyroid function in euthyroid sick syndrome. SETTING The study was performed at a university-affiliated pediatric intensive care unit (PICU). DESIGN This was an observational cohort(More)
OBJECTIVE To investigate the time course of thyroid function, factors that affect it, and its relationship to outcome in children surviving meningococcal septic shock. DESIGN AND SETTING Observational cohort study in a university-affiliated pediatric intensive care unit (PICU). PATIENTS AND PARTICIPANTS We divided the 44 children admitted to the PICU(More)
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