Marieke E Willemse

Learn More
Most relapses in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are not predicted using current prognostic features. Here, we determined the co-occurrence and independent prognostic relevance of 3 recently identified prognostic features: BCR-ABL1-like gene signature, deletions in IKZF1, and high CRLF2 messenger RNA expression(More)
Malignant cells infiltrating the bone marrow (BM) interfere with normal cellular behaviour of supporting cells, thereby creating a malignant niche. We found that CXCR4-receptor expression was increased in paediatric precursor B-cell acute lymphoblastic leukaemia (BCP-ALL) cells compared with normal mononuclear haematopoietic cells (P < 0·0001). Furthermore,(More)
Rearrangements of TCF3 (E2A) occur in o5% of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases. In 90–95% of these rearranged cases, TCF3 (chromosome 19p13) is fused to PBX1 (chromosome 1q23). This TCF3-rearranged subtype is characterized by the expression of cytoplasmic immunoglobulin heavy chain (CyIgm) in more than 80% of pediatric(More)
  • 1