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PURPOSE The aim of this study was to validate a gradient-based segmentation method for GTV delineation on FDG-PET in NSCLC through surgical specimen, in comparison with threshold-based approaches and CT. MATERIALS AND METHODS Ten patients with stage I-II NSCLC were prospectively enrolled. Before lobectomy, all patients underwent contrast enhanced CT and(More)
Classical experiments on the ability of cats to turn in the air during a free fall, the air righting reflex, have shown that vestibular and visual cues can play a role in this behavior. The development of this air righting reflex in kittens blinded since birth has been studied. The results show that the development in the blinded kittens is the same as in(More)
PURPOSE To compare the mid-position (MidP) strategy to the conventional internal target volume (ITV) for lung tumor management in helical TomoTherapy, using 4D Monte Carlo (MC) plan simulations. MATERIALS AND METHODS For NSCLC patients treated by SBRT (n = 8) or SIB-IMRT (n = 7), target volumes and OARs were delineated on a contrast-enhanced CT, while(More)
Metabolic imaging by positrons emission tomography (PET) offers new perspectives in the field of non-small-cell lung cancer radiation therapy. First, it can be used to refine the way nodal and primary tumour target volumes are selected and delineated, in better agreement with the underlying tumour reality. In addition, the non-invasive spatiotemporal(More)
PURPOSE To evaluate the impact of intra-fraction motion induced by regular breathing on treatment quality for helical tomotherapy treatments. MATERIAL AND METHODS Four patients treated by simultaneous-integrated boost (SIB) and three by hypo-fractionated stereotactic treatments (hypo-fractionated, 18 Gy/fraction) were included. All patients were coached(More)
Radiation-induced lung disease (RILD) is frequent after therapeutic irradiation of thoracic malignancies. Many technique-, treatment-, tumor- and patient-related factors influence the degree of injury sustained by the lung after irradiation. Based on the time interval after the completion of the treatment RILD presents as early and late features(More)
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